Research Associate (PhD student) Translational Melanoma Research (f/m/d) / 13712 / Clinic for Dermat

Research Associate (PhD student) Translational Melanoma Research (f/m/d) (Entgeltgruppe: EG 13 TV-L) Einsatzbereich: Clinic for Dermatology Stellen ID: 13712 Eintritt: Umfang: Teilzeit / 25,025 Std. Vertragsart: Befristet Befristung: 3 Jahre ab Besetzung gemäß § 2 Abs. 1 WissZeitVG Ihre Aufgaben: - Opportunity to conduct high-level interdisciplinary research within the newly established DFG-funded Collaborative Research Centre CRC/SFB 1752 “DYNAMO”, investigating the earliest mechanisms of therapy resistance in melanoma during the first days and weeks after therapy initiation: [https://www.uni-due.de/crc1752/](https://www.uni-due.de/crc1752/) - Work in Project B06 “Deciphering neutrophil heterogeneity and its implications for immune checkpoint inhibitor response in melanoma” - Investigation of neutrophil, melanoma, and T cell interactions in the context of immune checkpoint inhibitor (ICI) response and resistance in melanoma - Establishment of 2D and 3D melanoma culture systems as well as neutrophil–tumor–T cell co-culture models - Gene expression analyses (e.g. qPCR) and cytokine/chemokine profiling in tumor–immune interaction models - Multiplex imaging and spatial characterization of tumor–immune interactions - Contribution to experimental design and execution of immune-oncology focused and *in vivo* functional assays - Data analysis, interpretation, and integration of experimental results in collaboration with computational project partners - Participation in presentation of scientific results at meetings and conferences Ihr Profil: - Completed Diploma or Master degree in molecular biology or cancer biology, immunology, cell biology, bioinformatics, translational medicine or related disciplines - Strong interest in melanoma biology, tumor immunology, immune checkpoint therapy, translational cancer research, and tumor–immune interactions - Experience in molecular and cellular biology techniques - Experience with cell culture, cytokine profiling, flow cytometry and/or microscopy is desirable - Interest in multiplex/spatial imaging approaches (e.g. Phenocycler or related platforms) is advantageous - Experience with bioinformatics or biostatistics or mouse models is advantageous - Ability to work independently and in interdisciplinary teams, specifically bridging melanoma biology and tumor immunology - Ability to work closely with the second B06 project team and contribute to active scientific exchange - High level of self-motivation, scientific curiosity, reliability, personal initiative, creativity, and team-oriented personality - Enthusiasm for hands-on experimental and computational research and active contribution to a dynamic, international, and collaborative research environment - Strong organizational skills, commitment, and the ability to drive projects forward independently - Fluent in spoken and written English Freuen Sie sich auf: - Cutting-edge research & technology innovative project: o Participation in a newly established DFG-funded Collaborative Research Centre featuring a strong interdisciplinary translational focus on tumor dynamics and immune modulation in melanoma o Access to state-of-the-art technologies including spatial transcriptomics, multiplex imaging, cytokine/chemokine profiling, confocal microscopy, and AI-supported data integration - Networking & collaboration in the scientific community: o Integration into an interdisciplinary, internationally visible cancer immunology research network o Diverse teams: daily interaction with professional colleagues across experimental, computational, and clinical research o Exchange opportunities: excellent avenues for close scientific collaboration and external career development - Mentoring & career development: o Structured guidance: continuous, high-quality mentoring tailored to your academic progression o Enrollment into the Graduate School for Biomedical Science ‘BIOME’ ([https://www.uni-due.de/biome/) ](https://www.uni-due.de/biome/))o Skill building: active participation in CRC events, lab rotations, hands-on workshops, and specialized training activities - Work environment & infrastructure: o Top-tier facilities: excellent institutional infrastructure located directly at the University Hospital Essen campus o Work-life balance: a family-friendly working environment - Einen sicheren Arbeitsplatz im öffentlichen Dienst des Landes NRW - Faire Bezahlung nach Tarif (TV-L) inkl. Jahressonderzahlung und betrieblicher Zusatzversorgung - 30 Tage Urlaub im Kalenderjahr (bei einer 5-Tage-Woche) - Interdisziplinäres Arbeiten mit Kolleginnen und Kollegen aus anderen Fachbereichen - Arbeiten mit moderner Ausstattung und zertifizierten Qualitätsstandards - Familienfreundliche Unternehmenskultur, z. B. Betriebskindertagesstätte, Ferienprogramm für schulpflichtige Kinder, Beratung und Unterstützung durch die Abteilung für Familie & Gesundheit in allen Lebenslagen - Vielfältige Fort- und Weiterbildungsmöglichkeiten, bspw. in der Bildungsakademie des UK Essen - Gesundheitsmanagement, z. B. Betriebliches Eingliederungsmanagement, Impfungen, Förderung von Sportangeboten - Attraktive Zusatzleistungen, bspw. vergünstigtes Kantinenessen, Gemeinschaftsevents, Wohnheimplätze Rahmenbedingungen: Die Eingruppierung richtet sich nach den persönlichen und tariflichen Voraussetzungen., Schwerbehinderte Bewerberinnen / Bewerber und Gleichgestellte i.S. des § 2 Abs. 3 SGB IX werden bei gleicher Eignung bevorzugt berücksichtigt., Das UK Essen strebt eine Erhöhung des Frauenanteils in Bereichen an, in denen Frauen unterrepräsentiert sind. Sie werden zur Bewerbung aufgefordert und im Sinne des LGGs bei gleicher Qualifikation vorrangig berücksichtigt., Eine Bescheinigung gemäß §23a Infektionsschutzgesetz (IfSG) über den Impf- und Serostatus bzgl. Masern ist erforderlich.